A simplified and scalable synthesis of artesunate
نویسندگان
چکیده
ABSTRACT An efficient and economically viable approach for the large-scale conversion of artemisinin into the antimalarial frontline drug artesunate was developed. This advanced synthesis includes an NaBH4-induced reduction, followed by an esterification with succinic anhydride under basic conditions. The entire conversion follows the principles of green chemistry, i.e., application of reusable solvents. GRAPHICAL ABSTRACT
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عنوان ژورنال:
دوره 148 شماره
صفحات -
تاریخ انتشار 2017